Study on evaluation of monosodium glutamate induced oxidative damge on renal tissue on adult Wistar rats.

摘要: Objective To study the effect of monosodium glutamate (MSG) on biochemical parameters of renal tissue and certain blood parameters in adult albino rats. Methods Wistar rats of either sex (average weight of 200 g) were divided into control group and experimental group. The experimental group of rats received MSG intraperitoneally (4 g/kg/bw) for a duration of 30 days whereas the control group received distilled water intraperitoneally of the same volume. At the end of the experiment period, 2 ml of blood was collected through cardiac puncture for the estimation of the blood parameters. The kidneys were carefully dissected out and sliced into small pieces and centrifuged. The supernatant obtained was used for the estimation of lipid peroxidation, malondialdehyde (MDA), glutathione (GSH) and superoxide dismutase (SOD). Results There was an increase in the level of tissue lipid peroxidation (16-402±2-290, P < …