Synthesis and Antioxidant Activity of Some New 2-pyrazolin-5-one-1-carbothioamide Derivatives

摘要: A new series of 4-substituted-2-pyrazolin-5-one-1-carbothioamide derivatives 5, 7, 9, 10, 11 and 12 was synthesized through the reaction of 3-methyl-2-pyrazolin-5-one-1-carbothioamide (2) as a core compound with various electrophilic reagents. The structures of the newly synthesized compounds were confirmed by IR, H-1 NMR, MS and elemental analysis. They were evaluated for their potential antioxidant activity by using ABTS Radical Cation Decolorization Assay. Among the tested compounds, 2 and 9 displayed promising antioxidant activity against ABTS free radical.