Gelatin Methacryloyl Bioscaffolds: A Viable Option for Alveolar Bone Tissue Engineering? J Regen Biol Med. 2022; 4 (4): 1-4

摘要: The concept of tissue engineering involves the deposition of cells on bioscaffolds in a particular location that ultimately leads to regeneration of tissues. The combinatorial effect of cells, bioscaffolds and molecular signaling factors, works conjunctly to provide exact microenvironment mimicking the native in vivo system. Alveolar bone regeneration due to its location, poses certain challenges where appropriate mechanical loading and microbial flora need addressing during construction of the scaffold [1]. Three dimensional (3D) bioprinting has unfolded vast possibilities for bone regeneration through fabrication of 3D constructs that support adhesion and proliferation of pleuripotent stem cells in desired location. 3D printing allows individual-specific construction of scaffolds of a certain shape and size that allow regeneration of bone through cellular proliferation, differentiation, and molecular-signalling pathways in a guided fashion.The biomaterials used in alveolar bone regeneration requires component that supports mechanical and biocompatibility properties, and osteo-conductive properties. Certain biomaterials that have been utilized in the past and current times for bone regeneration are polylactic acid, polyglycolic acid, poly (lactate-hydroxyacetic acid), titanium alloy, biological ceramics, bioactive glasses and calcium phosphate [2]. Gelatin metharcylol (GelMA) is one such biomaterial which is known for its excellent biocompatibility, low antigenicity, and tuneable physical properties, which could be used alongside bone-marrow derived