Effect of colchicine in reducing inflammatory biomarkers and cardiovascular risk in coronary artery disease: a meta-analysis of clinical trials

摘要: Background:Colchicine's role in reducing inflammation and cardiovascular adverse events despite standard care in coronary artery disease (CAD) is controversial.Study Question:Can colchicine reduce inflammation [high-sensitivity C-reactive protein (hs-CRP)] in CAD?Data Sources:PubMed, Cochrane Library, and Trial registries.Study Design:The meta-analysis included 15 studies using add-on colchicine in patients with CAD. The outcomes evaluated were hs-CRP, white blood cell and neutrophil count, a composite end point of major cardiovascular events, myocardial infarction (MI), cardiovascular and all-cause mortality, and gastrointestinal adverse events. The analysis was performed using a random-effects model to calculate pooled mean difference and odds ratio (OR).Results:The meta-analysis revealed a mean reduction of 0.36 mg/L in hs-CRP levels [95% confidence interval (CI):− 0.51 to− 0.20] with add …