Efficacy and safety of fezolinetant for the treatment of menopause-associated vasomotor symptoms: a meta-analysis

摘要: OBJECTIVE:To evaluate the efficacy and adverse events of fezolinetant for treating vasomotor symptoms (VMS) of menopause.DATA SOURCES:PubMed/MEDLINE, ClinicalTrials. gov, EMBASE, Cochrane Database, Scopus, and WHO International Clinical Trials Registry Platform were searched through June 2023 for publications and randomized controlled trials on fezolinetant compared with placebo in menopausal women who experienced moderate-to-severe VMS.METHODS OF STUDY SELECTION:Our literature search identified 330 articles, of which five studies with six reports were included in our meta-analysis per our eligibility criteria.