41 SMALL INTESTINAL MICROBIOME DYSBIOSIS MAY UNDERLIE ABDOMINAL PAIN IN PATIENTS WITH DISORDERS OF GUT BRAIN AXIS INTERACTION.

摘要: AGAA b st ra ct s 40 PERIPHERAL MEDIATORS INVOLVED IN SENSORY NEURONS SENSITIZATION IN IBD PATIENTS IN REMISSION: A WINDOW ON A PAR1-MEDIATED MECHANISM OF IBD-ASSOCIATED PAIN Corinne Rolland, Perrine Rousset, Gaetan Poulen, Nicolas Lonjon, Florence Vachiery Lahaye, Luc Bauchet, Emmanuel Bourinet, Louis Buscail, Barbara Bournet, Cyrielle Giletta, Etienne Buscail, Guillaume Le Cosquer, Sylvie Sablayrolles, Bruno Le Grand, Celine Deraison, Nathalie Vergnolle Pain is a cardinal sign of inflammation and is associated with flares in Inflammatory Bowel Disease (IBD) patients. It is commonly accepted that inflammatory mediators released by inflamed tissues and infiltrated inflammatory cells are responsible for activation of peripheral nociceptors and activation of pain pathways. However, 30% to 50% of IBD patients in remission still report significant pain, despite the …