Cardiovascular Substructure Dose and Cardiac Events following Proton-and Photon-Based Chemoradiotherapy for Non-Small Cell Lung Cancer

摘要: PurposeRadiation therapy (RT) plays a critical role in treating locally advanced non-small cell lung cancer but has been associated with deleterious cardiac effects. We hypothesized that RT dose to certain cardiovascular substructures may be higher among those who experience post-chemoradiation (CRT) cardiac events, and that dose to specific substructures—the great vessels, atria, ventricles, and left anterior descending coronary artery—may be lower with proton- versus photon-based RT.Methods and MaterialsIn this retrospective review, we selected 26 patients who experienced cardiac events after CRT for locally advanced non-small cell lung cancer and matched them to 26 patients who did not experience cardiac events after CRT. Matching was done based on RT technique (protons vs photons), age, sex, and cardiovascular comorbidity. For each patient, the whole heart and 10 cardiovascular …