作者： E Eroglu , AB Waffo , VA Dennis , SR Singh , None
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摘要: Respiratory Syncytial Virus (RSV) causes serious lower respiratory tract diseases among infants. Unfortunately, no effective vaccine to prevent RSV infection has been developed. RSV fusion gene (RSV-F) is conserved among various strains of RSV. Therefore, an RSV-F DNA vaccine could confer long lasting protection against different RSV strains. Efficient delivery systems are required to increase the activity of DNA and/or protein vaccines for in vivo applications. Several nano-scale delivery systems are currently being studied for use as desirable vaccine delivery vehicles. These delivery nanomaterials could be very useful particularly for DNA vaccines. Encapsulation of these vaccines into nanostructures improves immunological properties. Poly hydroxyethyl methacrylate (PHEMA) nano-spheres coated by chitosan is one of the most promising vaccine candidate to improve delivery of either DNA or protein …