Evaluation of multifunctional dopamine agonists in modulation of α-synuclein induced aggregation and toxicity: Implication in neuroprotective treatment of Parkinson’s disease

摘要: ASN is a monomeric, natively unfolded, presynaptic, neuronal protein, containing 140 amino acids. In the presence of DA, ASN is known to form small soluble aggregates, known as oligomers. On the other hand, large insoluble aggregates of ASN, termed fibrils, are formed concentration dependently and in the presence of various metals. The toxic form of ASN, whether in oligomeric or fibrillar form, is not clear yet. We have developed D