Characterization of non-linear material parameters of atherosclerotic arteries using numerical and experimental models

摘要: Cardiovascular diseases are the leading cause of death worldwide. In most cases, cardiovascular diseases are caused by an underlying pathology: atherosclerosis. Numerical models are very helpful to study the biomechanics of atherosclerosis, assess the risks and more likely sites of rupture, to design and study the effect of interventions. Yet, the reliability of the simulations is directly dependent on the fidelity of the material properties, geometry and boundary conditions to represent the reality. However, data available to precisely model the mechanical behaviour of the plaque and its constituents are relatively limited, particularly for the inclusions.