Methods for determining a prognosis in multiple myeloma

摘要: 0005. The present inventors have developed a new approach to identifying patient groups with multiple myeloma, by combining analysis of genetic change taking place during disease progression with global expression analysis. The inventors have shown the Surprising importance of alterations in networks of gene expression in predicting clinical outcome in multiple myeloma. In particular, the inventors have shown the importance of alterations in expres sion of cell death genes.0006 Broadly, the present invention is based on the appli cation of array based technologies to characterize regions of copy number variation relevant to the pathogenesis of myeloma. Based on the results of these initial studies, the present inventors investigated the full range of genes inacti