Autoimmune atrophic gastritis and coeliac disease: A case-control study.

摘要: Background Autoimmune atrophic gastritis (AAG) is rarely associated with coeliac disease (CD). Aims To assess the frequency of AAG-CD association and to compare clinical, biochemical, and histological features of adults affected by both diseases (cases) with AAG controls. Methods This case-control study included 9 cases (F55%, median age 47, range 23-59yrs) matched (1: 3) by age (±4 yrs) and gender to 27 controls randomly selected from our AAG cohort (2009-2021). The AAG and CD diagnosis was based on internationally agreed criteria. Results Of 434 AAG patients (median age: 62.5 yrs, range18-92yrs, F: M ratio= 2.2: 1), 9 had a concomitant diagnosis of CD. The occurrence of AAG-CD association was 2% and 1.65% among AAG/CD cohorts, respectively. Cases were significantly younger than AAG cohort (n= 425, p= 0.002). In 4/9cases, AAG was diagnosed by proactive screening for autoimmune disorders. Autoimmune thyroid disorders were present in 5/9 cases. Cases had a significant higher prevalence of normocytic anaemia than controls (p= 0.004). No significant differences were found between cases and controls concerning clinical and histological features. Conclusions AAG-CD association is rare. Gastric and duodenal biopsies might be advisable in young people with normocytic anaemia and associated autoimmune disorders to timely diagnose clinically silent conditions.