FDG-PET/CT-based assessment of hematologic toxicity in anal cancer patients following chemoradiation

摘要: ResultsA total of 84 patients (74% women, 62.5 years median age, 58 Gy median tumor dose, 37 days median treatment time) with anal squamous cell carcinoma were included in this study. All patients underwent a FDG-PET scan prior to curative CRT. Lymphocyte counts were collected during and after treatment on a weekly to monthly basis. Lymphopenia was defined as lymphocytes nadir (LN) lower than 0.5× 109 cells/L (≥ grade 3, CTCAE v5. 0). The pelvic bones from the top of the iliac crest to 1-2 cm below the lesser trochanter of femur, as defined by CT, were used as a surrogate for total bone marrow (TBM). ABM