摘要: >> 2 fevers, and weight loss. Over the next 30 years, several physicians (WS Greenfield 1878, Carl Sternberg 1879, and Dorothy Reed 1902) provided the first pathologic descriptions of the characteristic malignant cells. 3-5 Physicians initially believed that Hodgkin disease was caused by an infection, such as tuberculosis. Despite studies in the early twentieth century confirming the malignant nature of this disease, it has only been in the last 10-15 years that the malignant cells were shown to be derived from clonal B cells, hence the current World Health Organization (WHO) designation as" Hodgkin lymphoma." ⁹