binds to Lp-PLA2 and inhibits the enzyme activity

摘要: AIM: Lipoprotein Phospholipase A2 (Lp-PLA2) plays crucial role in pathophysiology of atherosclerosis catalyzing the hydrolysis of platelet activating factor (PAF) and oxidized phospholipids. Many clinical studies have demonstrated that elevated Lp-PLA2 levels in plasma are correlated with increased cardiovascular risk. Clopidogrel as antiplatelet therapy is still one of the drugs of choice for cardiovascular patients. Apart from potent antiplatelet activity, clopidogrel exhibits various pleiotropic effects. We investigated the possible interaction of clopidogrel with Lp-PLA2 as well as the consequences of this interaction on the activity of Lp-PLA2 and its metabolism in vitro. MATERIAL-METHODS: We studied the possible interaction of clopidogrel with