A Novel Test of Low Contrast Reading in Non-Advanced Age-Related Macular Degeneration: A Potential Functional Endpoint for Clinical Trials.

摘要: Purpose: Purpose: The development of effective therapies for nonadvanced age-related macular degeneration (AMD) has been hindered by a lack of sensitive, reversible endpoints to be used in clinical trials. Many clinical reading tests (eg, MNREAD) use a relatively small number of words (10-20) and yield highly variable estimates of a patient’s reading rate (1). Our group developed a novel reading test, Ora Reading Passages™ test, that assessed patients’ reading efficiency algorithm under mesopic vision conditions, for naturalistic reading at low and high contrast. This study reports results from a third longitudinal visit for a cohort of non-advanced AMD patients tested in 2017.Methods: Methods: Nine non-advanced AMD patients with visual acuity of 20/25 or better from the original cohort (2017) and 16 matched controls returned for the third visit. During a single study visit, all participants completed a battery of …