The effect of Polyherbal Unani formulation on melanogenesis mechanism in the treatment of hypopigmentation disorder

摘要: Persons with hypopigmentary disorders are vulnerable to environmental intrusions and cosmetic psychosocial problems. In such circumstances, upregulating melanocytes in terms of proliferation and pigment synthesis is critical. Whereas hypopigmentation disorders can be treated several times, their effectiveness and safety remains unhappy. Due to their outstanding potentials in many treatments, naturally occurring plant extracts are being used widely. In this exploration, we gave one of these a trial. The current study aims to evaluate the impact of herbal Unani formulations which stimulate melanogenesis by modulating-accelerating activity and elucidating the mechanism underlying it. In this study, four Unani formulations, coded as UNIM-001, UNIM-003, UNIM-004, and UNIM-005 were dissolved into three solvents and made into extracts (Aqueous, Hydro-ethanol, and Methanol). The B16F10 cells were treated …