The expression of microRNA-30a-3p and estrogen receptor β in papillary thyroid cancer

摘要: Background A number of studies point to a significant role of microRNAs (miRNAs) in papillary thyroid cancer (PTC), where specific miRNA expression profiles associate with distinct clinical and biological phenotypes of the lesion. One of the microRNAs deregulated in PTC is miR-30a-3p. Evidence suggests that estrogen receptor β (ERβ), also found to be deregulated in PTCs, may directly regulate microRNA-30a-3p biogenesis and expression. Considering the possibility that ERβ might influence PTC cell behavior via miRNAs, in particular, miR-30a-3p, we have investigated their expression and correlation in PTCs with different clinico-pathological characteristics. Patients and Methods Quantitative PCR was used to determine the relative miR-30a-3p and ERβ expression levels in 37 pairs of PTCs and matched non-tumor thyroid tissues. Results The expression levels of miR-30a and ERβ were significantly altered in …