Utilization of cinnamaldehyde for synthesis of nitrogen-containing 2-hydroxy-1, 4-naphthoquinone derivatives as antioxidant agent

摘要: Cinnamaldehyde is the main compound in the cinnamon (Cinnamomum burmanii) that mostly applied in the essence and aroma industries and can be used as a medicinal product because of its bioactivities. This study aims to modify the cinnamaldehyde compound to 2-hydroxy-1, 4-naphthoquinone derivatives containing nitrogen and test their bioactivity as an antioxidant. The synthesis of 2-hydroxy-1, 4-naphthoquinone derivatives compounds was conducted which involves the precursors aromatic aldehyde variations (benzaldehyde, cinnamaldehyde, and 4-hydroxy benzaldehyde), and lawsone using iodine catalyst. The products were confirmed by UV-Vis, FTIR, and GC-MS obtained three 2-hydroxy-1, 4-naphthoquinone derivatives, namely 2-(hydrazino-phenyl-methyl)-3-hydroxy-2, 3-dihydro-[1, 4] naphthoquinone (compound 1), 2-(1-hydrazino-3-phenyl-allyl)-3-hydroxy-2, 3-dihydro-[1, 4] naphthoquinone …