Antinocieptive and anti-inflammatory effects of Toddalia asiatica (L) Lam.(Rutaceae) root extract in Swiss albino mice

摘要: MethodsThe antinociceptive and the anti-inflammatory effects of T. asiatica were investigated using formalin-induced pain test and the carrageenin-induced oedema paw. The extract solvent (vehicle), aspirin and indomethacin were employed as negative and positive controls respectively. Eight mice were used in each experiment.ResultsIn the early phase of the formalin test, the 100mg/kg dose showed no significant antinociceptive activity while the 200mg/kg showed significant (p< 0.01) antinociceptive activity. The 100 mg/kg dose showed highly significant antinociceptive activity (p< 0.001) in the late phase of the formalin test while the 200mg/kg dose showed no significant antinociceptive activity. A reduction in carragenin induced acute inflammation paw oedema was significant (p< 0.01) following administration of 100mg/kg dose but not with the 200mg/kg dose.ConclusionThe present study therefore lends …