Chemopreventive effect of Phyllanthus polyphyllus against N-Nitrosodiethylamine induced liver tumors by regulating liver enzymes, lipid peroxidation and antioxidants

摘要: This study was aimed to evaluate the chemopreventive effect of methanol extract of Phyllanthus polyphyllus (MPP) against N-nitrosodiethylamine (DEN, 200mg/kg) induced experimental liver tumor in male Wistar rats. Administration of MPP (200 and 400mg/kg) effectively suppressed liver tumor induced by DEN as revealed by decrease in DEN induced elevated levels of alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), gamma glutamate transpeptidase ((GTP), lipid peroxidation (LPO) and alfa feto protein (AFP). The extract also produced an increase in total proteins and enzymatic antioxidants [superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)] and non enzymatic antioxidants [Reduced Glutathione (GSH), Vitamin C and vitamin E] levels when compared to liver tumor bearing animals. Our data suggest that MPP may extend its chemopreventive effect by modulating lipid peroxidation, liver enzymes and augmenting antioxidant defense system.