Hepatic Progenitor Cells: Their Possible Role in Recurrent HCV and Allograft Loss Post-Liver Transplantation: 346

摘要: Purpose: HCV is the most common indication for liver transplantation (LT). The cholestatic variant of HCV (cvHCV) is characterized by rapid HCV progression leading to graft loss. Older donor age is associated with aggressive disease and rapid fibrosis progression. Ductular reaction (DR), believed to arise from hepatic progenitor cells (HPC) is associated with hepatic fibrosis. The aims of this study are (1) to demonstrate the HPC count and DR in the following three clinical outcomes of recurrent HCV: stable histology (no> stage 2 of 4 fibrosis), cirrhosis, and cvHCV and (2) to demonstrate the association between HPC, DR, and donor age.Methods: Using the LT database, a search for HCV cases from 1992–2007 yielded 903 cases, in which 203 had donor age> 60 yrs and 195 donor age< 30 yrs. Cases of re-LT, living donor LT, HIV, CMV, HBV co-infection, concurrent bile duct problem, and rejection were excluded …