作者： Deni Anggraini , Salman Umar , Helmi Arifin , Erizal Zaini
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摘要: Fenofibric acid is a potent lipid-lowering agent that is used clinically in severe hypertriglyceridemia, primary hyperlipidemia, and mixed dyslipidemia. Fenofibric acid is a poorly soluble drug which is classified as a Biopharmaceutical Classification System (BCS) class II. The purpose of the present study was to improve the solubility and dissolution rate of the poorly soluble drug fenofibric acid (FA) by the formation of a simple eutectic mixture with nicotinamide (NIC). A simple eutectic mixture of FA and NIC was prepared using the solvent-drop grinding method. A binary phase diagram of FA and NIC in various molar ratios was constructed by thermal analysis differential scanning calorimetry (DSC). Solid-state characterization was carried out using powder X-ray diffraction (PXRD) analysis, differential scanning calorimetry, Fourier transform-infrared spectroscopy analysis, scanning electron microscopy analysis, and …