Cerebro-Hemokinetics in Binswanger's Disease in Comparison with Senile Dementia of the Alzheimer's Type

摘要: Objectives Binswanger's disease (BD), which presents dementia associated with an extensive subcortical degeneration which is considered as ascribable to chronic ischemia, is now regarded as a subtype of vascular dementia. However, there are some divergence of opinion there about, and that still now, its morbid state is not always distinct. Recently, we determined regional cerebral blood flow (rCBF) in BD patients, in comparison with healthy normals and patients with senile dementia of the Alzheimer's type (SDAT), using N-isopropyl-p[ 1 2 3 I]iodoamphetamine ( 1 2 3 I-IMP) single-photon emission computed tomography (SPECT).Method The subjects were ten patients (four males and six females, mean age, 69.9 years), as diagnosed clinically and radiologically as BD at our department after 1990, and age-and sex-matched healthy normal controls (n=38) and patients with SDAT (n=55). No statistical deference of dimentia severity was found between patients with BD and SDAT, utilized Mini-Mental State examination, Hasegawa's dementia scale(-revised) and Nishimura dementia scale. Using 1 2 3 I-IMP SPECT, quantitative determination was made of rCBF at a total of 32 regions of interest (ROI). Data were analyzed using two-tailed Student's t tests to evaluate differences between groups for each ROI.Results Compared with normal control subjects, both patients with BD and SDAT showed significant decreased in rCBF at all ROI; the decrease was represented in the order of BD patients < SDAT patients < controls. Comparison between BD patients and SDAT patients, classifying ROI into frontal lobe, temporal …