55P High snail expression and activation of mTOR promote liver recurrence after hepatic metastasectomy for colorectal cancer

摘要: BackgroundMetastasectomy of liver metastases of colorectal cancer (CRC) offers the greatest likelihood of cure. Nevertheless, recurrence rates after this procedure are high, and chemotherapy is a reasonable choice with inconclusive evidence. In our study, we aimed to investigate the parameters that can be used to predict the development of recurrence after metastasectomy by examining clinical, pathological and molecular markers in primary tumor and their liver metastases.MethodsEpithelial-mesenchymal-Transition (EMT) mechanism, cancer stem cell markers (CSC) and RAS, mTOR, CMYC pathways were examined in primary CRC tissues and meastatic tissues of 84 patients.ResultsRecurrence occurred after metastasectomy in 40.5% of patients. While no difference was found between the development of recurrence and tumor localization, age, and pathological data, a significant relationship was found …