Microemulsion as drug delivery system for Peptides and Proteins

摘要: Microemulsions (MEs) are isotropic mixtures with or without a cosurfactant along with combination of oil, water and surfactant and most stable as per view of thermodynamics. These systems of drug delivery are currently of prior interest to the pharmacists because of their embryonic potential to act as therapeutic enzymes and peptide based drug delivery vehicles with incorporation of a wide range of active therapeutic protein and peptide molecules. These therapeutic macromolecules in microemulsion drug delivery form is not solely based on compositions of the vehicle but also on the internal structure or composition of the phases which may nurture protein drug distribution in the vehicles for enhanced drug solubilisation capacity, ease of preparation, enhancement of bioavailability and maximum shelf life. In order to appreciate the potential of protein based microemulsions as delivery vehicles for enhanced drug permeation via skin and tolerability of these systems, this review offers an overlook on phase behaviour studies formulation of microemulsion with entrapment and various approaches to incorporate proteins and enzymes into microemulsion, protein engineering methods for stable delivery and enhanced bioavailability, various protein drug compatibility study methods including characterization of microemulsions.