摘要: White adipocytes serve as an energy reservoir to store excessive calories in the form of lipid droplets and protect other tissues or organs from ectopic lipid accumulation. Brown adipocytes express uncoupling protein 1 and are integral to adaptive thermogenesis. Whereas the functions of adipocytes in either white or brown adipose tissues are well documented, our knowledge of bone marrow adipocytes (BMA) remains in its infancy. Bone marrow adipose tissue (BMAT) occupies approximately 50-70% of the bone marrow volume in human adults. 1 It is a dynamic tissue and responds to multiple metabolic conditions. For example, BMAT increases with obesity, aging, diabetes, caloric restriction, and irradiation. 2 Although the significance of BMAT expansion under these conditions is still largely unknown, BMA interact locally with hematopoietic and bone cells, and contribute to global metabolism through secretion of …