Design, development and evaluation of the repellent activity of Azadirachta indica oil-based solid lipid microparticles against Aedes aegypti (Linn).

摘要: The use of repellents has shown to be a practical and economical way of preventing mosquitotransmitted diseases. The aim of the study was to design, formulate and characterize Azadirachta indica (neem) oil based solid lipid microparticulate (SLMs) creams and thereafter evaluate its repellent activity against the Aedes aegypti mosquito. The oil was extracted from fresh leaves of Azadirachta indica using a soxhlet apparatus. The solid lipid microparticles (SLMs) were prepared using hot homogenization method. The stability of the formulated SLMs creams was evaluated by measuring the pH and particle size at determined time intervals. The morphology, encapsulation efficiency, loading capacity, FTIR analysis, skin irritation ability and mosquito repellence of the SLMs were also determined. The SLMs composed of both spherical and nonspherical particles and exhibited a slight decrease in the pH and an …