Biodegradable Chitosan Magnetic Nanoparticle Carriers for Sub‐Cellular Targeting Delivery of Artesunate for Efficient Treatment of Breast Cancer

摘要: Artesunate is a semi‐synthetic derivative of artemisinin, the active principle extracted from Artemisia annua. It possesses good anti‐proliferative activity and anti‐angiogenic activity with very low toxicity to normal healthy cells. The drawback of most cancer drugs is their inability to accumulate selectively in the cancerous cells. So, large quantities of doses have to be administered to get the required therapeutic concentration in the target site and it resulted in many serious side effects due to the exposure of healthy cells to higher concentrations of cytotoxic drugs. The problem may be solved by selectively and quantitatively accumulating the drug at target site using magnetic nanoparticles guided by an externally applied magnetic field. A modest attempt has been made in this present study, the artesunate magnetic nanoparticle was successfully formulated using two forms of chitosan and evaluated for its in‐vitro …