AGE-AND DOSE-DEPENDENT HAEMATOLOGICAL CHANGES IN LACTATIONAL LEAD-INTOXICATED RATS.

摘要: Objective: High to low lead (Pb) concentrations in breast milk has been found to perturb some biological events in the postnatal life. While postnatal Pb exposure has been reported to impair some haematological parameters in mammals, the age-dependent haematological signature of lactational Pb poisoning is not clear. This study investigated the effects of Pb exposure during lactating period on the haematological profile of rats at certain post-lactational ages using varying doses of Pb. Methods: Lactating mothers and their pups were randomly divided into 4 groups comprising 24 pups each. The treatment groups received 10 mg/dL, 30 mg/dL, and 70 mg/dL of lead acetate in their drinking water from postnatal day one (P1) to P21 of the lactating period. The control rats received distilled water. At P22, P60, P90 and P120, the pups from each group were euthanized and blood was collected and analyzed for blood …