Histomorphological aberrations associated with cannabis and caffeine exposure in the hippocampus of juvenile wistar rats

摘要: Cannabis and caffeine are two psychoactive substances often abused. Cannabis is illegal in many countries, yet it constitutes a social menace as individuals still abuse the substance. Caffeine on the other hand is legal and used almost without restrictions in most countries. It is also important to note that adolescence is a critical period of neural and mental development; and the juvenile brain might be typically vulnerable to certain consequences of psychoactive agents use and abuse. Notably, most existing literatures have considered the effects of these substances on the adult and matured brain. The aim of this investigation, therefore, was to assess the effects of caffeine and cannabis use on the histomorphology of the hippocampus of juvenile Wistar rats. Seventy two Wistar rats of both sexes were divided into six groups named AF. The Group A served as the Control. Group B were administered the higher dose of caffeine; Group C were administered the lower dosage of caffeine; Group D were administered the higher dosage of cannabis; Group E were administered the