Antibodies reactive with neutrophils following allogeneic haematopoietic stem cell transplantation

摘要: Allogeneic haematopoietic stem cell transplants might induce immunological alterations leading to autoimmune‐like syndromes. In particular neutrophil‐associated antigens could represent the target for autoantibodies against neutrophils in patients receiving an allogeneic peripheral stem cell or bone marrow transplantation, giving rise to granulocytopenia. With this aim we studied prospectively 43 allotransplanted patients for the presence of antibodies reacting with neutrophils (ARN), looking for a correlation with a post‐engraftment neutropenia. Our data showed that the direct test for ARN was positive in 30 patients. Interestingly, 7/7 patients who received a T‐cell‐depleted marrow transplant developed ARN. Antibodies with a specific neutrophil‐antigen reactivity were detected in 4 patients, 1 with an anti‐CD16/FcγRIIIb receptor reactivity and 3 with anti‐NA1 reacting patterns, respectively. From a clinical point of …