Human immunodeficiency virus (HIV)–and non-HIV–associated immunosuppression and risk of cervical neoplasia

摘要: OBJECTIVE:To estimate the risk of cervical intraepithelial neoplasia grade 2, 2–3, 3, adenocarcinoma in situ, or cancer (CIN 2 or worse) among women with human immunodeficiency virus (HIV)–and non-HIV–associated immunosuppression.METHODS:We performed a case–control study of 20,146 women with incident CIN 2 or worse and 5: 1 age-matched, incidence-density selected women in a control group (n= 100,144) enrolled in an integrated health care system from 1996 to 2014. Adjusted rate ratios (RRs) from conditional logistic regression were obtained for HIV status (stratified by CD4+ T-cells), solid organ transplant history, and immunosuppressive medication use.RESULTS:Risk of CIN 2 or worse was increased among women with HIV (n= 36 women in the case group and 79 women in the control group; adjusted RR 2.0, 95% CI 1.3–3.0) compared with those without HIV and in solid organ transplant …