Comparison of analgesic effect of agnogol with mefenamic acid in the treatment of primary dysmenorrhea

摘要: Background and Objective Primary DYSMENORRHEA is one of the most common complaints among women in reproductive age in that about half of young women suffer from DYSMENORRHEA. Nowadays, many people have a tendency to use a traditional medicine for DYSMENORRHEA. Hence, we aimed to compare the analgesic effect of AGNOGOL and MEFENAMIC ACID in the treatment of primary DYSMENORRHEA. Material and Methods This clinical trial was conducted on 44 women with primary DYSMENORRHEA referred to Hajar hospital in Shahrekord. The participants were randomly allocated to two groups of AGNOGOL (n= 23) to use one 3.2 mg AGNOGOL pill for three times a day and MEFENAMIC ACID (n= 21) to use 250 mg MEFENAMIC ACID every 8 hours a day for three days. The pain severity was detected by Visual Analogue Scale. We used Independent and Paired t test for comparing the means of quantitative variables and Chi Square for qualitative variables (P< 0.05). Results Considering age, menstrual duration, menstrual interval, and pain severity score, there was no significant difference in two groups at the beginning of the study (P> 0.05). After intervention, a significant reduction was found in the mean of pain score over time in both AGNOGOL (P< 0.001) and MEFENAMIC ACID (P< 0.001) groups, but the difference between two groups was not significant (P> 0.05). Conclusion Given the same effect of AGNOGOL in mitigating DYSMENORRHEA, we recommend it as an appropriate alternative for MEFENAMIC ACID.