Programme-28th ECNP Congress-Amsterdam 2015

摘要: Background: Ensuing from the psychoneuroimmunology hypothesis, neuroinflammatory activation of microglial cells is explored as a hallmark of neurodegenerative and neurodevelopmental aberrations in schizophrenia. Because extrapolation of preclinical research results to the human brain–particularly in pathological conditions–is limited, investigation of microglial activation in schizophrenia has been preferably investigated using immunohistochemistry on post-mortem brain tissue. Activated microglia express translocator protein (TSPO) on the outer mitochondrial membrane. TSPO ligand nuclear marker PET allows in vivo non-invasive visualization and quantification of neuroinflammation. Whereas previous studies in schizophrenia have used PET tracer 11C-PK11195, 18F-PBR111 is a novel second-generation tracer, with high specific TSPO binding and longer half-life.Objective: To compare different nuclear imaging methods for the study of microglial activation in schizophrenia and establish a protocol for 18F-PBR111 TSPO PET in schizophrenia patients and healthy controls.Method: We reviewed existing literature on TSPO nuclear imaging in schizophrenia on Pubmed, and subsequently performed a pilot study of 18F-PBR111 TSPO PET imaging on a Siemens Biograph mCTTM 64-slice, TrueV, ToF PET-scanner in healthy controls and schizophrenia patients (n= 9 per group).Results: Different markers have been developed for TSPO PET imaging, and the first generation tracer 11C-PK11195 has so far been most frequently used. Newer TSPO markers offer higher specificity but require genotyping of subjects for the rs6971 polymorphism …