Evaluation of Aerosol Delivery with a Vibrating Mesh Nebulizer and a Breath Actuated Jet Nebulizer in a Spontaneous Breathing Patient Model

摘要: Methods:In line with US FDA guidance, aerosol droplet size (volumetric mean diameter) was determined using laser diffraction (Spraytec, Malvern, UK). Inhaled aerosol dose was determined for both a vibrating mesh nebulizer (Aerogen Solo and Ultra, Aerogen Ltd., Ireland) and a breath actuated jet nebulizer (Aeroeclipse II, Monaghan Medical, Canada) using a standard 3 ml volume of 0.83 mg/ml salbutamol. The nebulizer mouthpiece was connected to a breathing simulator (ASL5000, IngMar Medical, US) via a collection filter, using an applied adult (V t 500 ml, BPM 15 and I: E 1: 1) or paediatric breathing pattern (V t 155 ml, BPM 25 and I: E 1: 2). 3.5 LPM supplemental gas flow was used for both nebulizers, in line with their respective instruction manual-stated ranges. Aerosol dose, expressed as a percentage of the nominal dose, was determined by UV spectroscopy at 276 nm. Time to delivery of the dose was also recorded (minutes: seconds).Results:The results are shown in the table below. Significance was considered at p< 0.05.Droplet Size (microns) Aerosol Dose (%)Nebulizer Adult Breathing Pattern Paediatric Breathing PatternAerogen Solo/Ultra(Vibrating Mesh Nebulizer)4.56 34.83±1.23(6: 30)22.90±1.30(6: 32)Aeroeclipse II BAN(Breath Actuated Jet Nebulizer)4.55 20.70±1.53(8: 22)8.29±0.87(9: 00)p-value N/A 0.0002< 0.0001Conclusions:Despite emitting near identical droplet sizes, aerosol dose delivery was observed to be significantly greater with the Aerogen Solo and Ultra in comparison with the Aeroeclipse II BAN system during simulated adult (p-value= 0.0002) and paediatric breathing (p-value=< 0.0001). Time to delivery of …