VP49. 02: Prediction of preterm prelabour rupture of membranes

摘要: ObjectivesTo identify early pregnancy risk factors for preterm prelabour rupture of membranes (PPROM) and develop a predictive model.MethodsRetrospective analysis of a cohort of mixed-risk singleton pregnancies screened in the first and second trimesters in three Danish tertiary fetal medicine centres. Univariate and multivariate logistic regression analyses were employed to identify predictive maternal characteristics, biochemical and sonographic factors. Receiver operating characteristic (ROC) curve analysis was used to determine predictors for the most accurate model.ResultsOf 3,477 screened women, 50 (1.4%) had PPROM. Maternal factors predictive of PPROM in univariate analysis were PAPP-A< 0.5 MoM (OR 2.23 [1.08–4.65] p= 0.03), previous preterm birth (OR 3.90 [1.51–10.04] p= 0.005), previous cervical surgery (OR 3.18 [1.53–6.64] p= 0.002), cervical length< 25mm on transvaginal imaging (first …