Comparison of Metabolic Profile of Lean and Obese Patients with Type 2 Diabetes Mellitus

摘要: Background: Obesity induced insulin resistance has long been used to explain the development of type 2 diabetes mellitus (T2DM). However, it cannot be used to explain the development of T2DM in lean individuals. Given the lifelong morbidity associated with T2DM and its sequelae, it is necessary to properly understand the disease process. Therefore, this study was designed to compare the physical and biochemical parameters in lean and obese patients of T2DM.Materials and Methods: We included newly diagnosed patients of T2DM and categorized them as lean (BMI< 18.5 kg/m2) and obese (BMI> 25 kg/m2) individuals; 30 patients in each of the two groups. Routine biochemical parameters such as fasting blood glucose (FBG), 2-hour post-prandial blood glucose (PPBG) and lipid profile were estimated using autoanalyzer. Glycated hemoglobin (HbA1C) levels were estimated in whole blood using BIO-RAD …