Quantum binding energy features of the drug olmesartan bounded to angiotensin type-1 receptor in the therapeutics of stroke

摘要: Stroke is the second most common cause of mortality worldwide and the third most common cause of disability. Stroke causes and hemodynamic consequences are heterogeneous, making blood pressure management in stroke patients complex. Knowing that hypertension is the most prevalent risk factor for stroke, the use of antihypertensive drugs to reduce blood pressure is also essential for the prevention of cardiovascular events before and after stroke. Evidence from clinically relevant studies demonstrates a reduction in morbidity and mortality due to angiotensin type-1 receptor (AT1) blockers. In excessive activity in the brain, this receptor can promote exaggerated sympathetic and hormonal responses caused by stress, vulnerability to cerebrovascular ischemia, and brain inflammation. In addition to its preventive effect, the antihypertensive drug olmesartan medoxomil has shown promising activity in the …