High‐throughput Assay and In Vivo Screen Identify α‐2, 3‐sialylation of CD98 by ST3GAL1 and ST3GAL2 as Essential to Melanoma Survival

摘要: Melanoma is an aggressive type of skin cancer that accounts for most skin cancer deaths, and the incidence of melanoma has increased rapidly over the past decades. Early‐staged disease can be cured by surgery, however, a lack of curative treatments for patients with established melanoma metastasis results in significantly low survival rates. Thus, identification of key drivers in melanoma progression is essential to our understanding of melanoma biology. Glycosylation is a hallmark of cancer biology and altered glycosylation influences multiple facets of both tumor growth and progression. Herein, we utilized lectin microarrays to compare the glycomes of early transformation and melanoma progression. We found common glycan signatures, including an increase of α‐2,3‐sialosides, in both biological processes, and revealed glycans associated with site‐specific metastasis. Tandem analysis of using an …