Glycomic Profiling Unveils Association Between Serum Glycosylation and Antibody Responses to Influenza Vaccines

摘要: Despite being the most powerful approach to tackle influenza infections, current influenza vaccines have a mixed record of protection across the population. In the 2019‐2020 flu season, flu vaccines in the U.S. were ~ 40% effective. High‐risk populations, such as the obese and elderly, tend to have weaker responses to influenza vaccines, the molecular mechanisms behind which remain poorly understood. Glycans play critical roles in the human immune system. In this study, we examined serum glycosylation of 160 Caucasian adults pre‐ and post‐vaccination with the 2019 Fluzone® Quadrivalent Vaccine using an expanded version of our lectin microarray technology that included antibodies against innate immune lectins and select sera glycoproteins. Glycosylation profiles were examined in light of post‐vaccination antibody responses. Results showed that obese participants who exhibited poor antibody …