Anti-inflammatory and antioxidant activities of Lantana radula Swartz and its phenylethanoid glycosides

摘要: Many species from the genus Lantana (Verbenaceae) have been used in traditional medicine, and their anti-inflammatory and antioxidant activities demonstrated. Lantana radula Swartz has been reported to be rich in phenylethanoid glycosides, which have various biological properties. In order to evaluate the actions of this plant, studies were performed on anti-inflammatory activity of the aqueous phase resulting from the fractioning with HP-20SS resin (AP-20SS) of L. radula roots, as well as on antioxidant capacity of its isolated phenylethanoids. Anti-inflammatory activity of the AP-20SS (30, 100, and 300 mg/kg) was evaluated using carrageenan-induced paw edema and peritonitis models. Antioxidant activity of the AP-20SS and its phenylethanoid glycosides (1 to 100 μg/ml) was evaluated by quantification of nitric oxide radical generation and lipid peroxidation. The AP-20SS reduced paw edema (100 and 300 …