Physicochemical, mechanical and antimicrobial evaluation of an antibiotic-anesthetic film for burn wound treatment

摘要: The goal of this work was to characterize films for the treatment of burn wounds. Films containing hyaluronan, sodium alginate, glycerin, lidocaine and ciprofloxacin (CL-films) were obtained by solvent casting method. The average thickness was 181±5 pm and the swelling index was 2. Powder X-ray diffraction patterns showed changes in the microstructure of CL-films, assigned to intermolecular interactions between the components, which were confirmed by FTIR spectroscopy. Thermogravimetric analysis indicated a water content of 20% which was unaffected by the presence of glycerin. Glycerin improved stretch-ability and smoothness of the films, showing elongation at break (59±7%), tensile strength (23.7±0.5 mPa) and Young's module (37±3 mPa) values that are appropriate for topical administration. The morphology and mechanical properties were examined by SEM/EDS and optical and polarized light …