Extranodal natural killer/T‐cell lymphoma nasal type in a western population: Molecular profiling identifies new therapeutic targets

摘要: To the Editor: Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL-NT), is an aggressive lymphoma characterized by its universal association with Epstein–Barr virus (EBV). It typically affects the nasal/oropharyngeal area, although in some patients, involves other extranodal sites. ENKTL-NT has a distinct geographical distribution, occurring more commonly in East Asia and Latin America than in North America and Europe, where it is a rare disease. 1 The prognosis is extremely poor under conventional anthracycline-based chemotherapy. Drugs that are generally unaffected by multidrug resistance pathways, such as L-asparaginase-based regimens, have yielded better responses, and the prognosis of these patients has improved in the last years, although survival is still poor compared to other lymphomas. For this reason, there is an urgent need for effective therapy. In recent years, novel molecular …