Combined Effect of Estrogen Replacement and Angiotensin II Type I Receptor Blocker on Endothelial Dysfunction and Oxidative Stress in Ovariectomized Rats

摘要: Background: Estrogen deficiency occurring after menopause leads to many problems as increased arterial blood pressure and enhanced oxidative stress. It also causes up regulation of angiotensin-II type1 receptors which is a common modulator for endothelial dysfunction. This causes increase in the prevalence of cardiovascular and coronary heart diseases in postmenopausal women.Objective: In this work, we aimed to elucidate the possible beneficial effect of concomitant administration of angiotensin-II type1 receptor blocker (AT1-RB), estrogen replacement on endothelial dysfunction, and oxidative stress in ovariectomized rats.Materials and Methods: Ovariectomy was done under ether anesthesia. Rats were left to have 1week rest for wound healing. Rats were divided into 5 groups (n= 8): Non-overictomized control group, overiectomized non-treated group, estradiol benzoate-treated group (3 µgm/100 gm BW …