The Promise of Metabolomics and Exposomics in CKDu

摘要: Chronic kidney disease of un-known cause (CKDu, also called Mesoamerican nephropathy) is a form of nondiabetic, nonhypertensive CKD most often described in impoverished agricultural communities. The strongest evidence to date indicates that heat stress is an important factor in the pathogenesis of CKDu in many, although not all, affected populations. Other nephrotoxic exposures, including agrochemicals, metals and metalloids, infections, and medications, may also contribute to disease development, either in isolation or in conjunction with heat exposure. The natural history of the disease may include recurrent acute kidney injury (AKI) leading to eventual chronic disease. 1