Serum lipids and thyroid hormone level changes in epileptic children on valproate mono therapy: is there a relation?

摘要: Background Valproic acid is an effective antiepileptic drug for treatment of many types of epilepsy. Although it is well tolerated, many effects on endocrinal and metabolic functions have been reported. Objectives to determine serum lipids and thyroid hormones in epileptic children receiving valproate. Patients And Methods 20 epileptic children (aged 3–16 years) on valproate therapy for3 months and 10 apparently healthy children as controls were enrolled in the study. All patients and controls were assessed for serum lipids, thyroid hormones, liver function and some hematologic parameters. Results The mean serum levels of serum lipids and thyroid hormones in patients were not statistically significant different from those of the controls (p> 0.05). Also, the mean serum levels of serum lipids and thyroid hormones were not significantly different between male and female. No significant correlations could be found between serum levels of thyroid hormone and lipid profile in patient group. Conclusions neither serum lipids nor thyroid hormones were altered by using Valproic acid as a mono therapy in epileptic children.