European Tissue Repair Society Focus Meeting Tissue Repair, Contraction, and the Myofibroblast Nyon, Switzerland November 18–20, 2004 The following compilation of abstracts represents a partial list of submissions received for presentation at the meeting. Please note the abstracts are arranged in alphabetical order (by presenter's name). Communications by the invited speakers will be published in a book by Landes Bioscience.: TGF‐β1 Signaling is Regulated by Negative Feedback Mechanism of BMP‐7 in Fibrotic Kidneys of Hereditary Nephrotic Mice

摘要: ICR‐derived strain with gulomerulonephrisis (ICGN) mouse derived from ICR mouse is a newly established mouse strain with hereditary nephrotic syndrome. The affected ICGN mice consistently show the clinical signs of nephrotic syndrome, developing various degrees. The lesions consist of thickened capillary basement membrane, enlarged mesangium without cellular proliferation, and tubulointerstitial fibrosis. Based on these histopathological findings and clinical biochemical data, ICGN strain mouse is considered to be a good experimental model for human idiopathic nephrotic syndrome. Extracellular matrix (ECM) components provide structural integrity to the tissues, and mediate regulation of cell growth, migration, differentiation, etc. The damaged cells have increased secretion of ECM components. This is a kind of self‐protecting reaction that is associated with healing process against injury. However, the …