Formulation, Characterization and Efficiency Evaluation of a Hydrogel Formulated with Algerian Thermal Water

摘要: Guergour thermal water (GTW) is commonly used in the east of Algeria for treating atopic dermatitis (AD) and psoriasis. Previous works demonstrated its chemical composition rich in minerals and heavy metals. The aims of the present study were (a) to possibly formulate a Hydrogel with GTW as an active agent (b) study the rheological properties and the stability of this Hydrogel (c) study the clinical efficiency of this Hydrogel towards atopic dermatitis symptoms.First, several excipients with both inert physiochemical properties and ability to endure the high salinity of the thermal water were chosen. Second, a Hydrogel was formulated with the thermal water as the major component, carrying out rheological properties and stability studies. The Hydrogel was then tested on patients having AD problems during two weeks. For that, a comparative study was conducted with a Hydrogel with the same formula, but prepared with purified water as vehicle. The evolution of AD symptoms and signs were evaluated based on questionnaires for different considered patients.