Detailed analysis and correlation of survival with subventricular zone dosimetry in patients diagnosed with glioblastoma treated with focal conformal radiotherapy: results of a prospective trial

摘要: Introduction: Several recent retrospective analyses have shown conflicting correlation of doses of radiotherapy (RT) to SVZ with survival in patients with glioblastoma (GBM). We present the results of a prospective study evaluating RT doses received by SVZ in patients diagnosed with newly-diagnosed GBM and their impact on survival. MATERIAL AND METHODS: Between 2012-2016, 100 patients with newly diagnosed GBM were accrued in this IRB approved prospective study. 80 patients who completed their adjuvant treatment form the study group for the present analysis. Patients underwent maximal safe surgical resection followed by adjuvant focal conformal RT to a dose of 59.4 Gy/33 fractions with standard concurrent temozolomide and 6-12 adjuvant temozolomide chemotherapy. We did not specifically consider SVZ during RT planning, which was done as per standard criteria of tumour bed+2-3 …